Abstract Title: Reactivation history of continental lithosphere of the Great Basin RegionÑProterozoic to Present Abstract Author(s): Karlstrom, Karl E. (University of New Mexico) Abstract: The lithospheric structure of the western U.S. represents an interaction of structures that formed during the Proterozoic (assembly to Rodinia breakup), and structures that formed or were modified during Cenozoic tectonism. This interaction of old structures and young driving forces, at lithospheric scale, provides a set of ongoing natural ÒexperimentsÓ that can be used to understand geodynamics of continents. This research involves collaborative investigations involving teleseismic studies, geologic studies that add ground truth and the time dimension, and geodynamic models that test realistic physical models. One of the most fundamental questions concerns the extent to which mantle velocity variations at 10-100 km scale are old and influenced by ancient lithospheric structure of North America, as opposed to young upwellings of asthenosphere and displacement of lithosphere due to small scale mantle convection. In the Great Basin region, mantle velocity variations coincide with both old structures (and Cenozoic tectonic provinces), such as: the Cordilleran miogeoclinal hingeline (Colorado Plateau edge), Great Falls tectonic zone (Snake River Plain), Proterozoic shear zones (Virgin Mountains), and Mojave-Yavapai province boundary (St. George lineament. Hence, a working hypothesis is that mantle velocity variations can represent original differences in bulk composition, thickness, and state of hydration of the Proterozoic lithosphere and that these compositional variations have been accentuated by different fertility and partial melt content of different mantle provinces due to asthenospheric upwelling in the Cenozoic. If so, present lithospheric structure cannot be understood without understanding both neotectonics and cumulative lithospheric evolution.